These cytokines and growth factors may act via autocrine signalling as other studies have reported.34 Sustained activation of PSCs can disrupt the biomechanical balance of nearby microenvironments, thus contributing to invasion of PDACs.35 Thus, BAG3‐positive PSCs remodel tumour microenvironment favourable for migration and invasion of cancer cells through multiple key cytokines/chemokines. The gene discussed is BAG3; the disease is neoplasm.