Multiple studies indicate that AML1‐ETO alone is not sufficient to induce AML in a murine model and thus additional genetic events are required for the onset of AML.4 AML1‐ETO rapidly induces murine leukaemia in cooperation with Wilm's tumour‐1 (WT1),5 suggesting that AML1‐ETO is considered as the important onset oncogene for the leukemogenesis of AML. The gene discussed is RUNX1T1; the disease is leukemia.