RUNX1 and leukemia: For example, MLT increases the transcription of the ubiquitin‐activating enzyme, E1, as well as transcription of the ubiquitin ligase, E3.45 Our previous study indicates that honokiol, a natural phenolic compound isolated from the plant Magnolia officinalis, induces proteasomal degradation of AML1‐ETO oncoprotein via increasing the expression of E2‐ubiquitin conjugase UbcH8 in leukaemia cells, indicating that AML1‐ETO protein is degraded through the UbcH8‐mediated ubiquitin‐proteasome system.