8 AML1‐ETO enhances the self‐renewal capacity of HSPC through COX‐β‐catenin signalling.9 Therefore, eliminating AML1‐ETO protein might inhibit the self‐renewal capacity in AML patients with t (8;21). Our previous study has shown that honokiol, a natural phenolic compound isolated from the plant Magnolia officinalis, rapidly degrades AML1‐ETO protein via increasing ubiquitin conjugase UbcH8 expression.10 However, whether agents degrading AML1‐ETO protein present anti‐self‐renewal of LSC is not yet determined. Here, RUNX1 is linked to acute myeloid leukemia.