COPB2 and neoplasm: Meanwhile, multivariate logistic analysis validated that COPB2 expression (OR = 1.348, 95% CI = 1.001‐1.815, P = 0.049), tumour size (OR = 1.581, 95% CI = 1.133‐2.205, P = 0.007), age (OR = 0.494, 95% CI = 0.365‐0.670, P < 0.001), ER status (OR = 2.027, 95% CI = 1.403‐2.929, P < 0.001) and clinical stage (OR = 53.116, 95% CI = 25.591‐110.246, P < 0.001) were significant high‐risk factors of LNM by using all parameters (Table 5).