As showed in Table 4, Univariate cox regression analysis indicated that the high COPB2 expression was independent high‐risk factor as well as tumour size(≥2 cm), old age (≥60), ER status and clinical stage (HR = 1.296, 95% Confidence Interval [CI] 1.019‐1.647, P = 0.035; HR = 2.383, 95%CI 1.793‐3.168, P < 0.001; HR = 0.631, 95%CI 0.495‐0.804, P < 0.001; HR = 1.684, 95%CI 1.255‐2.261, P = 0.001; HR = 48.887, 95%CI 23.756‐96.503, P < 0.001 respectively). This evidence concerns the gene COPB2 and neoplasm.