The present study highlights three extremely important points regarding the care for heart failure patients: (a) hyperuricemia was a predictor of a poorer long‐term prognosis, (b) treatment with allopurinol, that is, xanthine oxidase inhibitor, had no influence on the patients' prognosis, (c) after setting up comparable groups using the propensity score, no difference in long‐term all‐cause mortality was observed between patients without hyperuricemia and those with untreated hyperuricemia. The gene discussed is XDH; the disease is heart failure.