The results indicated that androgen/AR interaction activates significantly Akt throughout the increase (2.3-fold) of its phosphorylation on Ser 473 at early stage of cancer cell line T24 and in nonmalignant transitional epithelial cell line HCV29 (1.86-fold) with slight difference in total Akt expression after 48 h (Fig. 3a). This evidence concerns the gene AKT1 and cancer.