Neither was there any significant difference in the LS mean AUC (± SE) of serum insulin concentrations in the high- and low-glucose studies, respectively, in patients with (96.4 ± 18.6 and 84.1 ± 18.3 mU * h/L) or without albuminuria (119.2 ± 17.2 and 102.1 ± 17.4 mU * h/L), or between the diabetes patient groups. This evidence concerns the gene INS and diabetes mellitus.