To test and verify the result, we did survival analysis on GSE74187, another GEO datasets which contain 60 GBM samples with overall survival (OS) and progress-free survival (FPS) time, with the same calculation strategy; it indicated that the expression level of RRM2 might be related to both OS and PFS (P<0.05) (Figures 6(c) and 6(d)), which is consistent with earlier investigation. The gene discussed is RRM2; the disease is glioblastoma.