RRM2 and glioblastoma: Our data suggested that pathogenesis and development of glioblastoma are regulated by complex gene network through different biological pathways; RRM2 is a core gene in this network and is associated with the prognosis of glioblastoma; it could be a promising target for efficient suppression of glioblastoma; however, further experiments and more efforts are needed to confirm it and illustrate the specific molecular biological mechanism.