Apparently, these genes take part in cell mitosis and cell cycle and are cancer related, even though precise mechanisms of how this PPI network worked are confused; this information adds value to the notion that the RRM2-related network is relevant in carcinogenesis and deserves further exploration in GBM; it may provide a novel avenue worth pursuing when developing effective drugs by combining RRM2 inhibitors (such as 3AP) with other agents. The gene discussed is RRM2; the disease is glioblastoma.