PTGS2 and mastitis: The anti-inflammatory potential of leonurine (considered by some authors a natural component of L. cardiaca [5]) on E. coli-induced mastitis in mice [33]: their results suggested that leonurine alleviates the histopathological changes, downregulates the levels of proinflammatory cytokines (TNF-α and IL-6), upregulates the level of anti-inflammatory cytokine IL-10, and inhibits the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).