For premenopausal breast cancer cases, multivariable logistic regression analyses adjusting for age, tumor size, nuclear grade, status of ER, and HER2 indicated that OW patients tended to have large tumor size (>5cm) (odds ratio [OR], 1.30; 95% CI, 1.05 to 1.62) and triple-negative breast cancer (OR, 1.31; 95% CI, 1.03 to 1.67) compared with NW patients. This evidence concerns the gene ESR1 and neoplasm.