Paradoxically, Sahin et al. found that overweight and obesity premenopausal patients had significantly less estrogen receptor- (ER-) positive tumors but more triple-negative tumors and higher stages of disease compared to normal-weighted patients, and human epidermal growth factor receptor-2 (HER-2)/luminal-like subtype was found to be significantly greater in postmenopausal overweight patients [9]. The gene discussed is ESR1; the disease is obesity due to melanocortin 4 receptor deficiency.