However, as we have stated earlier (Bhadra et al., 2011b) with the discovery of as MHC class I tetramers, T-cell receptor transgenic mice and ovalbumin expressing transgenic parasites will enable the investigation of the effector mechanisms from various CD8 subsets and their correlation with immune protection during acute and chronic phases of the infection with much greater clarity. The gene discussed is CD8A; the disease is infection.