Although IL-10 is associated with parasite persistence and dissemination (Bomfim et al., 1996; Anderson et al., 2008), it is also important for controlling the exaggerated inflammatory response associated with pathology observed in parasitic diseases such as malaria, Chagas disease, and leishmaniasis (Li et al., 2003; Costa et al., 2009, 2015; Gautam et al., 2011). This evidence concerns the gene IL10 and malaria.