Similarly, in other cancers, PIK3R1 downregulation has been proved to be an independent prognostic marker in breast cancers (35) and to promote propagation, migration, epithelial–mesenchymal transition, and a stem-like phenotype in renal cancer cells through the AKT/GSK3beta/CTNNB1 pathway (36). This evidence concerns the gene AKT1 and breast cancer.