In addition, NAMPT is particularly overexpressed in mesenchymal GSCs, where its expression is correlated to a hypomethylation state driven by depletion of methionine and de novo methyltransferases, sustaining mesenchymal GSCs rapid growth and NAM consumption to support NAD+ utilization and sustain DNA hypomethylation (15), another marker of poor GBM prognosis. Here, NAMPT is linked to glioblastoma.