ENSG00000251605 and Alzheimer disease: Qiu Hong et al. demonstrated that mitochondrial respiratory function (R3, R4, RCR, P/O, and OPR), complex enzyme activities (succinate dehydrogenase, NADH dehydrogenase, and CytC oxidase), and the expression of cytochrome oxidase II subunit mRNA were significantly reduced in cerebral tissue from AD model, and the Tiao Xin preparation significantly improved these indicators [13].