GRIN2A and Alzheimer disease: JinGuoqin et al. demonstrated that the Tiao Xin preparation reduced amino acid transmitter content (excitogenic amino acid transmitters (Glu, Gln, and Asp) and inhibitory amino acid transmitters (Gly, Tau, and GABA)) and the expression of NMDAR mRNA (NR1a and NR2a) for AD prevention and treatment [12].