Intraperitoneal administration of geniposide at 2.5, 5, and 10 mg/kg inhibited mammary gland apoptosis, Bax expression, and the phosphorylation of caspase-3 cleavage and p53 and augmented Bcl-2 expression in LPS- (0.2 mg/mL) induced mastitis model mice. The gene discussed is TP53; the disease is mastitis.