Geniposide at 75 mg/kg regulated antiapoptotic functions and suppressed blood-brain barrier leakage/haemorrhage by increasing GluN2A-containing N-methyl-D-aspartate receptor expression in transient middle cerebral artery occlusion rats, and these effects could be counteracted by GluN2A antagonist NVP-AAM077, but not the GluN2B inhibitor ifenprodil. Here, GRIN2A is linked to medical procedure.