As a repressor of the p38/MAPK pathway, TOB1 can suppress p38/MAPK signaling by decreasing phosphorylation of p38 and ATF2 (Sun et al., 2013; Ng et al., 2017); p38/MAPK acts as an enhancer of adipogenesis contributes to obesity (Patel et al., 2003). The gene discussed is TOB1; the disease is obesity due to melanocortin 4 receptor deficiency.