In the present study, our GWIA for BMI found an interaction between EXOC4 and 1q23.1 that may contribute to the development of obesity, although this interaction did not pass the Bonferroni correction test, they had the lowest interaction P-value (P = 4.05 × 10-13) after accidental exclusion. The gene discussed is EXOC4; the disease is obesity due to melanocortin 4 receptor deficiency.