TARDBP and amyotrophic lateral sclerosis: In addition to nuclear functions in pre-mRNA processing, TDP-43 also represses translation of specific mRNAs in Drosophila ALS models and cultured mammalian cells (Majumder et al., 2012, 2016; Coyne et al., 2014, 2017), although the exact connection between these mRNAs and ALS remains unclear.