Moreover, we studied the prevalence of common polymorphisms in C3 c.941C>T, p.Pro314Leu (rs1047286), C3 c.304C>G, p.Arg102Gly (rs2230199), CFB c.94C>T, p.Arg32Trp (rs12614), CFB c.95G>A, p.Arg32Gln (rs641153) and THBD c.1418C>T, p.Ala473Val (rs1042579), which were previously reported in association with other immune-mediated diseases, including C3 glomerulopathy (33, 34), IgA nephropathy (35), and age-related macular degeneration (36–38). The gene discussed is C3; the disease is age-related macular degeneration.