CFH and age-related macular degeneration: At variance with LPVs, common genetic variants in complement genes predisposing to aHUS or to other immune-mediated diseases (as C3 glomerulopathy, age-related macular degeneration, and IgA nephropathy) (33–38) were not more abundant in our cases compared to “supercontrols.” Specifically, the CFH H3 haplotype, which has been strongly associated with an increased risk of aHUS (15), was rare both in cases and in “supercontrols,” although it was slightly more prevalent in cases.