CFHR1 and infection: Inspired by these reports, to identify other anti-FHs aHUS genetic determinants, here we adopted a similar approach using as “supercontrols” adults subjects with the homozygous CFHR1 deletion who did not get anti-FHs aHUS despite carrying the known genetic risk factor for the disease (i.e., FHR1 deficiency) and likely having been exposed to common infections during childhood.