IGF1 and bipolar disorder: Drug-naïve patients with bipolar disorder with manic episode showed increased serum levels of FGF-2, NGF, and IGF-1, while patients with MDD showed decreased serum FGF-2 levels that are probably associated with their compensatory roles of neuroprotection and angiogenesis, which are involved in their specific pathophysiology in these two disorders and thus be able to differentiate from each other (10, 11).