Data on the role of NLRP3 in colorectal cancer (CRC) pathogenesis is inconsistent, where some evidence suggests a pro-tumorigenic role for the inflammasome, while others identified that the inflammasomes protects against tumor (Allen et al., 2010; Huber et al., 2012; Guo et al., 2014; Wang et al., 2016). The gene discussed is NLRP3; the disease is colorectal carcinoma.