In addition to targeting NLRP3, miR-22 can also directly target the 3′-UTRs of SIRT1 (Li W.B. et al., 2013), and miR-22 mimics decrease the expression of SIRT1 protein in GBM cell lines (Li W.B. et al., 2013). Here, NLRP3 is linked to glioblastoma.