NLRP3 and neoplasm: Wang G. et al. (2018) demonstrated a positive correlation between NLRP3 expression and tumor size, lymph node status and IL-1β expression in OSCC tissue specimens and in vivo models of OSCC. Also, the authors showed that, silencing of NLRP3 in OSCC cell lines reduced cell proliferation, migration, and invasion in vitro (Wang H. et al., 2018). Additionally, high expression of the NLRP3 inflammasome mediates chemoresistance in OSCC (Feng et al., 2018). Therefore, downregulation of NLRP3 could have a therapeutic potential in OSCC.