It was shown that activation of NLRP3 leads to an abundant expression of IL-1β (Guo et al., 2018), which can trigger T helper type 17 (Th17) cell differentiations and osteoclasts activation in RA (Dayer, 2003; McInnes and Schett, 2011; Zhang et al., 2015b). The gene discussed is IL1B; the disease is rheumatoid arthritis.