The role of the NLRP3 inflammasome in the pathogenesis of several diseases was demonstrated, including CAPS, autoimmune disorders and cancers (Aganna et al., 2002; Martinon et al., 2006; Masters et al., 2009; Bauer et al., 2010; Wen et al., 2011). This evidence concerns the gene NLRP3 and autoimmune disease.