NLRP3 and rheumatoid arthritis: Recently, an indirect effect of miR-33 on NLRP3 activation was demonstrated in RA (Xie Q. et al., 2018), which could be explained by miRNA controlled dysregulation of mitochondrial function (Schroder et al., 2010; Zhou et al., 2011; Miao et al., 2014; Ouimet et al., 2015).