As BRN2 represses MITF and drives motility of tumor cells in vivo, the BRN2-MITF expression axis may be considered as a driver of melanoma invasion, in addition to TGFβ, JARID1B and β-catenin signalings (Goodall et al., 2008; Pinner et al., 2009; Hoek and Goding, 2010; Roesch et al., 2010). The gene discussed is POU3F2; the disease is melanoma.