About half melanoma patients carry a BRAF mutation and are typically given combined BRAF and MEK inhibitors such as dabrafenib and trametinib, vemurafenib and cobimetinib, and encorafenib and binimetinib (FDA-approved) (Cheng et al., 2013; Kugel and Aplin, 2014; Long et al., 2014, 2017; Rizos et al., 2014; Johnson et al., 2015; Dummer et al., 2017). This evidence concerns the gene BRAF and melanoma.