After single cell RNA sequencing of BRAF-mutated patient-derived xenografts which were subjected to combined drug inhibition, the authors identified one cell population with a major regulation of a NC stem cell gene signature driven by the activation of nuclear receptor RXRG. Moreover, pharmacological inhibition of RXRG could delay the drug resistance onset of melanoma cells (Rambow et al., 2018). Here, BRAF is linked to melanoma.