MAPT and Alzheimer disease: In tauopathies such as AD, intracellular Tau forms filamentous of hyperphosphorylated and aggregated protein inside the cells that is associated with the progression of neurodegeneration (Ballatore et al., 2007; Goedert and Spillantini, 2011; Arendt et al., 2016; Medina et al., 2016).