Although fibrillary and aggregated Tau, which are formed by hyperphosphorylated Tau, are considered a histopathological hallmark of tauopathies (Selkoe et al., 1982), monomeric forms of the protein are also involved in toxicity and the spread of the disease (Gomez-Ramos et al., 2006; Cowan and Mudher, 2013; Gerson et al., 2014; Bolos et al., 2017b; Perea et al., 2018a). Here, MAPT is linked to tauopathy.