In OM, axotomization exerted a 63.0% change to small RET+ neurons (Δ% = 27.5 ± 42.4 in C group; Δ% = −35.6 ± 11.9 in A group) and a 35.0% change to the large cells (Δ%=-14.1 ± 25 in C group; 21.9 ± 38 in A group). The gene discussed is RET; the disease is ocular melanoma.