CD4 and neoplasm: The overall proportion of T cells in the tumor had no significant increase (CD3+, Supplementary Fig. 11a); however, encouragingly, the number of both CD4+ (Fig. 6d) and CD8+ (Fig. 6e) T cells increased, while that of Treg population (CD4+Foxp3+, Fig. 6f) decreased, reflecting an activation of the adaptive immune response.