The ELISA quantification data indicated a down-regulation of pro-tumor cytokines (IL-10, VEGF-A, and TGF-β1) and an up-regulation of anti-tumor cytokines (TNF-α, IL-12 p70, and IFN-γ) in the acGM-1.8-treated group (Fig. 6g). This evidence concerns the gene TGFB1 and neoplasm.