Cardiomyopathy (CMP) is the most prevalent phenotype of laminopathies, a group of diseases caused by mutations of the nuclear lamina proteins Lamin A and C (Lamin A/C), which are encoded by LMNA. Lamin A/C are main components of the nuclear lamina, and play a key role in maintaining the structural integrity of the nucleus and in processes such as DNA replication, transcription and chromatin organization1–4. The gene discussed is LMNA; the disease is cardiomyopathy.