Of note, impairment of this dynamic reorganization of the genome has been shown during terminal differentiation of skeletal myoblasts from Emery Dreifuss Muscular Dystrophy patients, in human adipose stem cells and during differentiation of iPSCs towards the endothelial lineage in the presence of the lypodystrophy-causing R482W LMNA mutation43,48,49. Here, LMNA is linked to muscular dystrophy.