(Figure 1A) ARHL was associated with higher levels of CSF total tau (β = 0.23, p = 0.002) and ptau181 (β = 0.17, p = 0.017) after adjustment for age, gender, education, APOE4 status, pathological diagnosis, DM2, hypertension, hyperlipidemia, BMI, and extracted CSF volume. The gene discussed is APOE; the disease is hyperlipidemia.