Moreover, the longitudinal analyses showed that ARHL at baseline was associated with more rapid cortical thinning in hippocampus (Figure 3B) and entorhinal cortex (Figure 5A–5D) in preclinical or prodromal AD, after adjusting for age, gender, education, APOE4 status, DM2, hypertension, hyperlipidemia, BMI, and ICV. The gene discussed is APOE; the disease is Alzheimer disease.