The complex molecular pathogenesis of CLL involves microenvironmental stimulation via aberrant signaling including the B‐cell receptor (BCR), NF‐κB, IL‐4, and TLR pathways, among others (Abrisqueta et al, 2009; Zenz et al, 2010; Hallek, 2015; Stilgenbauer, 2015; Kipps et al, 2017). Here, NFKB1 is linked to B-cell chronic lymphocytic leukemia.