Motifs recognized by E protein (including TCF4), TCF7/LEF, NFAT, EGR, and Forkhead TF families were gained in CLL, while motifs that were lost in CLL were mostly from the EBF, ETS, NF‐κB, and JUN/FOS (AP‐1) families (Appendix Table S2). Here, TCF4 is linked to B-cell chronic lymphocytic leukemia.