These changes included reactivation of BCL2L11, CDKN1A, PIK3CB1, NFKBIA, MEF2C, and IRF3 in CLL, while BCL2, ZAP70, LEF1, ETS1, and RUNX1 were repressed (Dataset EV11). Here, RUNX1 is linked to B-cell chronic lymphocytic leukemia.