Among the top abundant genes differentially expressed due to CF were CCR1, CSF3R, CXCL1, CXCL3, and IL1B (Fig. 7 a), while those associated with CF phenotype included ATF3, FGFR1, HLA-DBP1, ITPR1, and LILRB1 (Fig. 7 b). The gene discussed is ITPR1; the disease is cystic fibrosis.