Among those predicted to be inhibited in the input CF-associated gene expression dataset were Interleukin 1 Alpha (IL1A), Nuclear Factor kappa B (NF-κB) complex, and C-C Motif Chemokine Ligand 5 (CCL5), while two inhibited upstream regulators (Triggering Receptor Expressed on Myeloid cells 1 [TREM1] and Tumor protein 53 [TP53]) were associated with CF phenotype. The gene discussed is IL1A; the disease is cystic fibrosis.