Transcriptional analysis showed preferential expression of TLR8 and TLR7 in the LNR-cDC and –pDC subsets respectively (as opposed to migratory DC), both in HLN and BrC SLN (Additional file 5: Figure S4A), which were the exact DC subsets we identified as affected in the breast tumor-draining SLN. Here, TLR8 is linked to breast neoplasm.