CD38 and neoplasm: Here we humanized 3G3 to have a SDR-grafted antibody, SG003, whose affinity to bind to CD38 was higher than Daratumumab, and the epitope of SG003 was different from that of Daratumumab; moreover, SG003 showed stronger ADCC function and in vivo inhibitory efficacy of tumor growth in xenograft mice model, suggesting its potential to achieve improved curative effect in patients with leukemia.