Active CYR61 enhancers, which are enriched in H3K27Ac, are not present in normal colon tissue and cells, but are found in CRC tissue and colon cancer cell lines (Fig. 2a, b, Additional file 1: Figure S2A), indicating that CYR61 enhancers are activated in cancer cells. The gene discussed is CCN1; the disease is colorectal carcinoma.