CCN1 and colon adenocarcinoma: ONCOMINE microarray dataset analysis from the Hong Colorectal dataset and Skrzypczak Colorectal 2 dataset showed that CYR61 mRNA was significantly up-regulated in primary colon adenocarcinoma tissues compared with normal controls (Fig. 1d, e), consistent with our tissue specimen analysis, indicating that CYR61 expression is up-regulated in primary colonic adenocarcinoma tissue.