Firstly, we analyzed ChIP-seq data, of colon adenocarcinoma samples and normal colon tissues, downloaded from the GEO database and found three putative enhancers located at 26.5 kb, 31.5 kb, 48.6 kb downstream of the CYR61 transcriptional start site (Fig. 2a), referred to as Enhancer1 (chr1:85605899–85,608,570), Enhancer2 (chr1: 85610948–85,613,635) and Enhancer3 (chr1: 85628077–85,630,633), respectively. Here, CCN1 is linked to colon adenocarcinoma.