However, at a 10 μM concentration, the antiproliferative effect of the inhibitor EE02 on the proliferation of the A549, H460, H1975, BT549 and MDA-MB-468 cancer cells was significantly stronger than that on the proliferation of the MCF-7 cells, which overexpress EPS8 but not EGFR (P = 0.003, 0.008, 0.008, 0.008 and 0.009, respectively, t-tests) (Fig. 2a and c). Here, EGFR is linked to cancer.