TTN and amyotrophic lateral sclerosis: We compared mRNA FC estimates in the current study to those obtained previously for exosome proteins altered in ALS patients compared to CTL subjects [65], which revealed a weak positive FC correlation (rs = 0.16, P = 0.25) and 5 mRNA-protein pairs with consistent changes in abundance (ALS-increased: THBS1; ALS-decreased: DPYSL5, SLC4A1, TTN, TLN1) (Additional file 16A).