Genes most strongly decreased in ALS blood included prostate and testis expressed 2 (PATE2), BCR, RhoGEF and GTPase activating protein (BCR), host cell factor C1 (HCFC1), and leukocyte immunoglobulin like receptor B1 (LILRB1) (Fig. 2). Here, HCFC1 is linked to amyotrophic lateral sclerosis.