ALS-increased DEGs nearest to susceptibility loci included interferon related developmental regulator 1 (IFRD1), TANK binding kinase 1 (TBK1), cAMP responsive element binding protein 5 (CREB5), ATP binding cassette subfamily G member 1 (ABCG1), selectin L (SELL) and annexin A3 (ANXA3) (Fig. 5d, f–j). This evidence concerns the gene ANXA3 and amyotrophic lateral sclerosis.