However, in other autoimmune diseases, Alexander et al. and Takatori et al. reported that Helios+ Tregs were expanded in active SLE but unaltered in RA [7, 24], These conflicting reports indicate the lack of knowledge regarding the functionality and the role of Helios-expressing Tregs in autoimmune diseases. The gene discussed is IKZF2; the disease is systemic lupus erythematosus.