RYR2 and Schnyder corneal dystrophy: A prominent RYR2 mutation that has been implicated in SCD is rs3766871 (p.Gly1886Ser), which is present in high prevalence in a molecular autopsy study involving 173 SCD cases, whereby rs3766871 has been demonstrated to result in an increased calcium ion oscillation in the cell and has been postulated to cause diastolic calcium ion leak [23].