Among the SCD-related genetic variations that have been identified in the SCN5A gene include: (i) rs7626962 (p.Ser1103Tyr), which causes an amino acid substitution in a conserved sequence between domains II and III of Nav1.5 [25]; (ii) rs11720524, which has been predicted to disrupt a transcription factor binding site of the gene [22]; and (iii) rs41312391, that modulates the expression of an adjacent gene that is implicated in the regulation of histone deubiquitinating complexes [26]. The gene discussed is SCN5A; the disease is Schnyder corneal dystrophy.