EIF4E and cancer: It has been increasingly clear from reports in the literature that the activity of the eIF4F complex contributes to resistance development against many types of therapies used in cancer treatment, e.g. Vermurafenib (B-RAF (V600E) inhibitor) [34], AZD8055 (mTORC1/2 inhibitor) [25] and receptor tyrosine kinase inhibitors such as erlotinib and cetuximab [51].