The high presence of territorial VN staining in tumors from patients with metastasic stage and unfavorable histology, would lead to higher migration ability of tumor cells by anchorage to fibers and proteoglycans, as well as disrupted cell adhesion and spreading via interactions with specific ανβ3 and ανβ5 integrins, uPAR and PAI-1 in a stiff matrix. This evidence concerns the gene SERPINE1 and neoplasm.