Our previous studies have reported that EA could relieve neurological disorders, reduce infarct volumes after focal cerebral ischemia (Wang et al. 2009) and regulate the Reperfusion Injury Salvage Kinase (RISK) signaling pathway (ERKε, PKC, GSK-3β, STAT3) via cannabinoid receptor 1 (CB1R)(Wang et al. 2011) and inhibit neuronal apoptosis(Guo et al. 2015; Sun et al. 2016; Wei et al. 2014; Zhou et al. 2013). This evidence concerns the gene CNR1 and nervous system disorder.