Comparing with MHCC-97H-Con, the DElncRNAs in the MHCC-97H-ROCK1 mainly affected immune response, apoptosis and proliferation and cancer; the DElncRNAs in the MHCC-97H-ROCK2 clustered in endosomal/vacuolar pathway, antigen processing, p53 signaling pathway, STAT signaling and so on. Here, TP53 is linked to cancer.