DM is classified in two main categories: type 1, due to cellular-mediated autoimmune pancreatic islet β-cells destruction which occurs in 5–10% of cases, and type 2 (T2DM), due to insulin resistance (IR) with a defect in compensatory insulin secretion, which affects 90% of diabetic patients [2]. This evidence concerns the gene INS and type 2 diabetes mellitus.