CCN2 and neoplasm: Stiffness induces p300 nuclear accumulation and the p300-dependent transcription of the key fibrogenic genes α-smooth muscle actin (α-SMA) and connective tissue growth factor (CTGF), in addition to a panel of secreted profibrogenic and tumor-promoting factors including CXCL12, IL11, IL6, PDGFA and B, and VEGFA [45].