Intriguingly, the level of adiponectin was also unexpectedly high in group M. It might be that with the increase in adipocytes, more adiponectin was secreted as well, but its functional effects were offset by the relatively lower mRNA expression of adiponectin receptors adipoR1 and adipoR2 in group M compared to CGN and, to some degree, SCGN. The gene discussed is ADIPOQ; the disease is childhood gender nonconformity.