We have previously observed that the protein cross-linking enzyme TG2 is prominently expressed at the cancer/stroma boundary in CRC [6], and TG2 cross-linking of the ECM is known to slow invasive behaviour of cancer cells [16], pointing to a role for this enzyme in supporting the desmoplasia and enhanced collagen synthesis in response to invading tumours. Here, TGM2 is linked to colorectal carcinoma.