TGM2 and cancer: However, these processes result in a stiffer ECM, and enhanced biomechanical signalling in response to increasing tissue stiffness can induce aggressive behaviour in cancer cells [17,18], Accordingly observations made by other groups have linked enhanced stromal TG2 to poor prognosis in some cancers, including CRC [31,32], and our study supports the observation that TG2 expression is linked to poorer outcome in terms of tumour recurrence and overall survival in CRC [32].