TGM2 and colorectal carcinoma: Therefore, the objectives of this study were to examine the relationship between TG2 and the biomechanical environment through modification of the ECM, to understand the differential impact of epithelial and stromal TG2 using specific TG2 knockdown approaches in an in vitro system, and to link these functional observations to imaging-based fibre alteration measurements in the collagen rich ECM observed in patients with CRC.