Interestingly, silencing TG2 expression in the SW480 cells resulted in a loss of the enhanced cluster growth promoted by silencing TG2 in the fibroblasts (Figure 2F), suggesting that CRC-derived TG2 contributes to driving growth of the clusters, in a mechanism that then involves fibroblast-derived TG2. Here, TGM2 is linked to colorectal carcinoma.