Moreover, our previous study suggested that 5-O-acetyl-renieramycin T, a modified compound of RT, exerted a potential to suppress cancer stem cell (CSCs) growth, which is represented by a decrease in the CSCs markers CD44 and CD133 due to depletion of the protein kinase B (AKT) signal resulting in apoptosis induction of CSCs [56]. This evidence concerns the gene CD44 and cancer.