Of note, when NF1 and RASA1 are co-mutated, they identify a subtype of non small cell lung cancers with higher sensitivity to MEK inhibitors [72]; this genotype likely identifies a subtype of tumors that do not present other oncogenic mutations in the RAS/RAF/ERK axis and are therein sensitive to the pharmacological inhibitors of this pathway. The gene discussed is MAPK1; the disease is non-small cell lung carcinoma.