CIDEA and obesity due to melanocortin 4 receptor deficiency: In addition, while Cidea and Cidec are predominantly expressed in adipocytes, and are poorly represented in the normal liver, their expression increases dramatically in the human steatotic liver [40] and a single nucleotide polymorphism of a G to T transversion in CIDEA exon 4, which is equivalent to a V115F substitution, is associated with higher body mass index in Swedish obese patients [50,51,52], and obesity and metabolic syndrome in Japanese and Chinese populations [50,51,52].