In line with these reports, we presented the evidence that the mRNA expression for antioxidative enzymes SOD-1, SOD-2, and GPx but not HO-1 mRNA was markedly increased in force exercising mice with colitis as compared with the mRNA expression of SOD-1, SOD-2, and GPx in sedentary mice with colitis. The gene discussed is SOD1; the disease is colitis.