However, our present study supports and further extends previous observations that the prolonged and intensive exercise could lead to escalation of inflammatory responses as manifested by the increase in the lipid peroxidation, as well as gene and protein expression of HIF-1α and release of inflammatory markers, finally leading to exacerbation of colitis and marked impairment of the healing of these inflammatory changes in colonic mucosa of obese and non-obese animals. Here, HIF1A is linked to colitis.