Figure 6A–F shows the results of mRNA expression of proinflammatory biomarkers HO-1 (A), iNOS (B), and COX-2 (C) and the protein expression of HO-1 and HIF-1α in the colonic mucosa of sedentary or treadmill exercising mice fed either SD or HFD with TNBS-induced colitis. This evidence concerns the gene NOS2 and colitis.