Figure 5D–F (right panel) shows the results of mRNA expression for SOD-1, SOD-2, and GPx-1 in the colonic mucosa of sedentary or exercising mice with TNBS-induced colitis fed a SD or HFD. The expression of mRNA for SOD-1, SOD-2, GPx, and HO-1 was not significantly altered in colonic mucosa of sedentary mice fed HFD compared with those in animals fed SD. In contrast, the expression of mRNA for SOD-1, SOD-2, and GPx mRNA, was markedly increased in colonic mucosa of mice subjected to forced treadmill exercise as compared to sedentary mice fed both diets (p < 0.05) (Figure 4D–F). This evidence concerns the gene SOD2 and colitis.