SOD1 and colitis: In contrast, the colonic mucosal contents of GSH and SOD were substantially increased in the colonic mucosa of mice subjected to forced treadmill exercise fed either SD and HFD and administered with TNBS as compared with the respective values of GSH and SOD in sedentary mice with experimental colitis fed SD or HFD (p < 0.05) (Figure 4B,C).