The hereditary form of TTR amyloidosis is an autosomal dominant disease caused by single-point mutations in the TTR gene that originate TTR variants with reduced stability prone to dissociation into non-native monomers, which in turn rapidly self-assemble into oligomers and ultimately amyloid fibrils that accumulate in the nervous system, heart, kidneys and eyes. The gene discussed is TTR; the disease is autosomal dominant disease.