This last observation in particular may overlap with that, by Zeng and co-authors [31], about a trend of CXCL14 overexpression in IDH wt gliomas vs IDH mutant ones: G-CIMP tumors in fact were closely related to IDH mutation, and a better prognosis characterizes patients carrying them [26,34]. This evidence concerns the gene CXCL14 and central nervous system cancer.