GJA8 and cataract: This interpretation supports our previous data suggesting that Cx50D47A impairs the trafficking and/or stability of wild-type Cx50 and Cx46 in the lens.13 Similarly, Cx46fs380, a Cx46 mutant, may inhibit its own trafficking to the plasma membrane and that of the co-expressed wild-type Cx46 and Cx50 in the lens.31 Thus, reducing the levels of co-expressed wild-type connexins may be a general mechanism by which expression of mutant lens fiber connexins leads to dominantly inherited cataracts.